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While XOR dependent redox mechanisms were implicated in adipogenesis, the potential impact of UA per se on adipocyte differentiation has not been determined.
Recently, microRNAs (miRNAs), known to modulate gene expression through post-transcriptional mechanisms, were implicated in regulation of early pregnancy events including maternal recognition of pregnancy and implantation.
Previous studies showed that polyQ tracts are incompletely digested by eukaryotic proteasomes, which then become sequestered in aggregates (Holmberg et al., 2004), but no mechanisms were implicated.
Serotonergic and dopaminergic mechanisms were implicated in both forms of impulsivity with a wider range of serotonergic mechanisms (each with a small effect) potentially influencing cognitive impulsivity.
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004): 1. Enhanced oxidative stress 2. Disproportional K8/K18 expression together with keratin modifications 3. Chaperone dysfunction 4. Elevated p62 levels 5. Insufficient protein degradation Ad 1.
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Altogether these findings support the view that nonischemic mechanisms are implicated in the pathophysiology of TBI.
The etiology in most of the cases is unknown and several pathogenic mechanisms are implicated in secondary OD.
Several mechanisms are implicated, including endothelial dysfunction, altered balance between levels of vasoconstrictive and vasodilating substances, glycocalyx alterations, and interactions with circulating cells (Figure 1).
Cell death is critical for diverse physiological processes and dysregulation of cell death mechanisms is implicated in various pathological conditions such as cancer and neurodegenerative disease.
Multiple concurrent mechanisms are implicated in the processing of pain signals, and thus, administration of combinations of drugs has been recommended for the management of this debilitating type of pain.
Dopaminergic mechanisms may be involved in the pathophysiology of posttraumatic stress disorder (PTSD), although the evidence for this is limited; serotonergic mechanisms are implicated largely by virtue of the modest efficacy of serotonergic drugs in the treatment of the disorder.
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