Sentence examples for mechanisms we next from inspiring English sources

To further investigate CXCL12-mediated guidance mechanisms, we next examined expression of CXCR4 and CXCR7, the two receptors that bind CXCL12 [39].

PTH increases COX-2 expression and subsequent synthesis and release of prostaglandins [56].ecause both PTH and PGE2 decrease Sost transcription through cAMP/PKA mechanisms, we next examined whether the capacity for PTH to decrease Sost required prostaglandins.

Given our goal of comparative analysis of transcriptional control mechanisms, we next performed differential expression analysis for all known TFs (Fig 1D).

To get more insight into the underlying mechanisms, we next we performed transient cotransfections of a Smad4 expression construct with all three wild-type promoter-reporter constructs into Smad4-deficient SW480 cells (data not shown).

As EDNRB and GNA11 siRNA impact pigment formation in our screen and regulate melanogenesis by well-characterized mechanisms, we next sought to experimentally validate novel EDNRB pathway components identified by our method.

To relate the impaired LTP to a molecular mechanism, we next examined intracellular signal transduction during the induction of LTP.

For a more detailed and intuitive understanding of the underlying mechanism, we next analyzed the transformation of the shape of f-I curves with temperature.

To further explore the molecular mechanism, we next assessed transcript levels for factors that may stimulate PGCs proliferation within E11.5 gonad.

Given the biochemical evidence in support of the displacement mechanism, we next built a mathematical model to determine if obligatory displacement could account for the synergy we observed in our bulk polymerization assays.

Having established that Txl1 is a Trr1 substrate and is oxidized in response to low levels of H2O2 by a Tpx1-dependent mechanism, we next examined whether Txl1 regulates Pap1.

To test the validity of this mechanism, we next looked to see whether Fyn, which shows increased activity after PAG knockdown, was indeed responsible for phosphorylating CTLA-4 in primary T cells.