In this mechanism, we cannot check the number of particle on orifice plate.
Owing to the limited number of validation loci available for each size band or for each type of formation mechanism, we cannot correlate the false-discovery rate with the size spectrum and the formation mechanism of the variants with high confidence.
Although we favor the idea that α cells possess an intrinsic glucose sensing mechanism, we cannot rule out the involvement of the β cell metabolite GHB (γ-hydroxybutyrate), recently proposed to mediate the inhibitory effect on glucagon secretion (Li et al., 2013).
Since it is well known that rodent adherent BM cells might contain HSCs over long periods caused by emperiopoiesis [20] among other mechanisms, we formally cannot exclude a contamination of MSC preparations with remaining HSCs.
Hence, unless sustainability is built into the company's compensation schemes - including its performance appraisal, bonus payment, and career advancement mechanisms - we cannot expect middle managers to align their attitudes and actions behind sustainability goals.
We are not aware of data in direct support of this mechanism, but we cannot formally exclude it.
We conclude that NRC-03 and NRC-07 directly kill breast cancer cells by a membranolytic mechanism, although we cannot rule out the possibility that NRC-03 and/or NRC-07-induced pore formation in mitochondria may contribute to cytotoxicity.
This finding may touch on a compensatory mechanism; however, we cannot exclude that visually impaired children undergo a different learning process whereby they learn to function better autonomously than children with normal vision.
While some of the 800 drugs in development have similar mechanisms of action, we cannot necessarily rely on testing with one member of a drug class to tell us what will happen with other members.
There will always be interventions that are needed if we are to study mechanisms but which we cannot make in the human brain: for example, selective depletion of different transmitters can reveal their contribution to the workings of specific areas in monkeys [ 53].
