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Mechanisms underlying variable weight loss (WL) response after Roux-en-Y gastric bypass (RYGB) are poorly understood.
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The TSE agents associated with the two PrPres phenotypes identified in the brain or spleen still need to be biologically characterized and, more generally speaking, the basic mechanisms underlying the variable tissue or cell tropisms of different prions inside the central nervous system and in the peripheral tissues are still little understood.
This is undoubtedly because the molecular mechanisms underlying continuously variable phenotypes are harder to decipher.
In this work, we aimed to establish a mathematical model of ER-dependent gene expression to explore potential mechanisms underlying the variable actions of SERMs.
12, 21 Elevated testosterone in this patient is unexpected; however, the mechanisms underlying the variable effect of NR5A1 mutations are still not clearly understood.
These revised models are useful to better understand the mechanisms underlying the variable progression of Lewy body diseases so that diagnostic and therapeutic strategies are improved.
This measure is also useful in ruling out a confound of spatial ability as the underlying variable between mechanism understanding and mathematical strategy use.
Indeed, understanding the modifying and compensatory mechanisms that underlie variable expressivity and penetrance might point the way to new therapeutic opportunities.
In particular, our understanding of physiological/biochemical mechanisms underlying halophytes under variable salinities is very scarce.
These heterotic expression genes among different genotypes provided new avenues for exploring the molecular mechanisms underlying heterosis, including variable gene expression patterns.
Issues that remain to be addressed are the mechanism underlying the variable histologic subtypes of PIK3CA-H1047R-induced mammary tumors and the effects of PIK3CA-H1047R on luminal/basal cell differentiation.
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