Sentence examples for mechanisms underlying progressive from inspiring English sources

The results further suggest that the changes in TMD variability resulting from bone remodeling are of importance and may provide an insight into the understanding of the mechanisms underlying progressive failure of vertebral bodies and development of a clinical fracture.

The major mechanisms underlying progressive scarring of the liver (fibrogenesis) have been explored and consolidated in the past few years [ 1, 3].

As such, one of the central and formidable challenges in systems biology is to develop multiscale computational models and methods that can be used to study molecular mechanisms underlying progressive diseases [ 60- 65].

In patients with Wolfram syndrome, these mechanisms underlie progressive neurodegeneration and endocrine dysfunction.

To date, the mechanisms underlying the progressive loss of dopamine neurons in Parkinson's disease remain unknown.

One important question raised by our work concerns the mechanisms underlying the progressive nature of the ND2 mutant phenotypes.

The mechanisms underlying the progressive neurodegeneration in PD are still elusive and the discovery of the active or main driving force is of paramount importance in the search of effective therapeutic strategies.

While morphologic and biochemical aspects of degenerative joint disease (osteoarthritis [OA]) have been elucidated by numerous studies, the molecular mechanisms underlying the progressive loss of articular cartilage during OA development remain largely unknown.

There is a pressing need in particular for insight into pathological mechanisms underlying the progressive form of MS, as most available treatment options in use or under development are targeted toward relieving the relapsing form of disease.

In light of the above results, we next aimed to better understand the mechanisms underlying the progressive normalization of cytosolic AA pools that takes place in Salmonella-infected cells at 3 4 h p.i. (Tattoli et al., 2012).

Although neural selective vulnerability is not uncommon in mitochondrial-associated diseases, including Leigh syndrome, Leber's hereditary optic neuropathy and Alpers' syndrome (Bianchi et al., 2011; Koopman et al., 2013), further studies will be required to understand the mechanisms underlying the progressive tissue-specific nature of mitochondrial disease.