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Postnatal manipulations such as brief (early handling, EH) and long, daily mother offspring separations (maternal separation, MS) in rats are used to study the mechanisms underlying developmental plasticity of stress and fear responses, and to model stress-related disorders in humans and in non-human animals.
The molecular mechanisms underlying developmental programming are poorly understood but may involve the interplay between genetic and epigenetic processes, and prenatal environmental factors such as maternal mood.
The lack of mutants in this and other fleshy-fruited species has hindered thorough studies on the genetic and molecular mechanisms underlying developmental differences between dry and fleshy fruits.
In order to discover the mechanisms underlying developmental system drift, it is necessary to systematically and quantitatively investigate the structure and dynamics of evolving regulatory networks.
Functional magnetic resonance imaging (fMRI) studies investigating the neural mechanisms underlying developmental dyscalculia are scarce and results are thus far inconclusive.
The investigation of early environmental effects can inform the fields of toxicology and environmental epidemiology by elucidating the mechanisms underlying developmental exposure and disease risk later in life.
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Neither the reasons behind this limitation nor the mechanism underlying developmental plasticity are currently understood.
Oxidative stress has also been implicated in a variety of programming models as a potential mechanism underlying developmental programming in the offspring.
This finding reveals an important potential mechanism underlying developmental improvement in VWM performance, and one which in developmental terms may be more plausible than positing a step change in maximum VWM capacity.
Activity-induced persistent synaptic modifications are generally thought to be the cellular mechanism underlying developmental refinement of neuronal connections (Zhang et al. 2001), as well as learning and memory in mature animals (Bliss and Collingridge 1993; Chapman et al. 1999; Martin et al. 2000).
Despite the known importance of somatic cells for oocyte developmental competence acquisition, the overall mechanisms underlying full developmental competence acquisition are far from being understood.
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