Sentence examples for mechanisms underlying alterations from inspiring English sources
In order to further understand the molecular mechanisms underlying alterations in learning and memory in mice fed different caloric diets, we investigated the SIRT1 signaling pathway.
The ApoGlow™ Adenylate Nucleotide Ratio Assay (Cambrex) was used to determine the effect of miR-183 overexpression on distinct mechanisms underlying alterations in cell viability.
The mechanisms underlying alterations in brain development are far from being understood in animals and even less in humans, but new molecular techniques and imaging methods may hold the key to growing knowledge of normal and corrupted developmental trajectories.
Therefore, the aim of the present study was to uncover, through a combined strategy based on an innovative high-throughput technology (microarray) and classical molecular methodologies, the mechanisms underlying alterations in cell metabolism featuring patients with CKD.
Therefore, in addition to transcription factors and other DNA/RNA-binding proteins, comprehensive investigations into transcriptional mechanisms underlying alterations in global gene expression patterns should also consider the emerging role of miRNAs [ 18].
Possible mechanisms underlying alterations in NGF-induced pain behaviour were explored using indomethacin pretreatment, histopathological evaluation of synovitis, and rtPCR for NGF receptor (tropomyosin receptor kinase (Trk -A) expression in dorsal rooTrk -Alia (DRG).
However, most studies suggest that endothelium dysfunction might be one potential mechanism underlying alterations on the elasticity of atherosclerotic vessels, supporting our findings about immediate changes in endothelial function (FMD) and delayed changes in arterial stiffness (pulse waveform measures) in association with increasing PM.
The second objective was to begin dissecting the molecular mechanism(s) underlying alterations in guanosine triphosphatase activity.
The inherent manipulability of the ruminal fermentation has largely been explored by altering substrate (i.e., diet composition) or by adding specific metabolic inhibitors (e.g., of methanogenesis), but the limits to which the fermentation can be altered, and the mechanisms underlying these alterations, have not been firmly established (Ungerfeld 2015).
There are many complex mechanisms underlying epigenetic alterations such as DNA methylation, histone modification and gene regulation by non-coding RNA, of which DNA methylation is the most common [ 42].
However, the mechanisms underlying pathological alterations in the brain transcriptome are incompletely understood.
