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Autoreactive T cells are normally controlled by Tregs and other regulatory mechanisms under normal circumstances, whereas in autoimmune diseases Treg dysfunction causes autoreactive T-cell proliferative responses and tissue damage [ 37].
The constrained diode architecture permits the simultaneous existence of multiple charge transport mechanisms under normal operating conditions making this an interesting system for further study.
By understanding these mechanisms under normal conditions, treatments can be designed for diseases of the mucous production of the ocular surface.
Implementation of nanoscratch analyses in conjunction with high resolution microscopy techniques is an approach to study the tribological behavior of nanostructured coatings and to gain information about their plastic deformation mechanisms under normal and lateral loads.
We suggest that endogenous HIC is down-regulated through similar mechanisms under normal cellular conditions.
The core body temperature is tightly regulated around a set point by homeostatic mechanisms under normal physiological conditions.
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Indeed, microarray analyses supports the hypothesis that intronic miRNAs are usually expressed in coordination with the host gene mRNA in human tissues [ 4, 5], strongly suggesting that co-transcription from the host gene promoter is the most common transcriptional mechanism under normal conditions.
Overconsumption of these types of food overrides the homeostatic mechanisms, which under normal circumstances regulate appetite and body mass, leading to hedonic eating.
The harmful effects of the mature peptides may be assessed by increasing their quantities beyond the ability of the receiving cells to counter their noxious effects to which they are usually exposed or by removing any other mechanisms that under normal circumstances counter these harmful effects, such as enzymes that degrade the mature peptide or bind it.
Pathogenic processes use the same molecules and mechanisms which operate under normal conditions.
Open image in new window Fig. 2 Regular, double-layer space truss, layout and preferred failure mechanism under uniform normal nodal loading.
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