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Tumor growth and metastasis require neovascularization, therefore, tumors use various mechanisms to shift the balance to an angiogenic inductive environment.
Here we have used recent evidence to speculate that regenerating appendages utilize several mechanisms to shift glucose metabolism toward anabolic pathways.
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A 5-year phase-out is a gentle mechanism to shift more of the funding overall to new investigators.
In this way, stimulation of ARF6-mediated endosomal recycling may act as a compensatory mechanism to shift endosomal transport equilibrium in favor of recycling, in turn alleviating cholesterol accumulation in the LE/LY.
The hydrolysis of pyrophosphate is an efficient mechanism to shift the very unfavorable equilibrium of ATPS reaction to the site of the products.
The authors suggest that this could be a mechanism to shift protection from changes in single base pairs in favor of protection from major damage to DNA [ 12].
Our novel data suggest that breast cancer cells may utilize this mechanism to shift PR transcriptional action toward target genes that drive cell proliferation and pro-survival pathways.
Work in mammalian systems suggests that Ire1 can be activated independently of an accumulation of unfolded proteins in the ER lumen, perhaps by utilizing such a mechanism to shift the oligomerization activation threshold [ 32].
A current working model suggests that endocrine feedback influences hypothalamic AMPK via a number of mechanisms designed to shift an organism from negative to neutral energy balance.
Bacteria have limited energy reserves, so they need robust mechanisms to quickly shift between rapid and slow growth, as well as a strategy for long-term survival during periods of prolonged starvation.
Although we intentionally delayed an in-depth discussion of these powerful mechanisms of evolution to shift allele frequencies, in hindsight, we could have introduced these concepts earlier in an activity or simulation to better prepare students conceptually for the lab.
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