Sentence examples for mechanisms to inactivate from inspiring English sources

Exact(7)

This partly results from the evolution of mechanisms to inactivate or silence the action of exogenous DNA.

Overexpression of Mad2 on the other hand leads to SAC activation, but as all kinetochores are attached, mechanisms to inactivate the SAC will be activated at the same time, too.

Promoter methylation is one of the major mechanisms to inactivate tumor-related genes, particularly tumor suppressor genes, along with genetic events, ultimately leading to carcinogenesis [ 9, 11].

As an essential tumor suppressor it is no surprise that human tumors demonstrate a diverse array of genetic mechanisms to inactivate p53 function.

Our data suggest that when cells are challenged with cytotoxic amounts of damaged DNA, they can use one of two mechanisms to inactivate Chk1.

As with other tumor suppressors, it is likely that miR-494 overexpression and LINE-1 insertions may represent just two possible mechanisms to inactivate MCC in liver cancer.

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Similar(53)

In the SAC, we propose that p31(comet) and TRIP13 catalyze a two-step MCC disassembly mechanism to inactivate the SAC.

Hence, we propose that filament formation is a general mechanism to inactivate and store key metabolic enzymes during a state of advanced cellular starvation.

Our images suggest that once the Aβ forms amyloid and condenses, it is less stimulating toward astrocytes and perhaps the formation of amyloid is a protective mechanism to inactivate the toxicity of soluble Aβ.

The most common mechanism to inactivate p53 function in human tumors is missense mutations; several compounds have been developed to restore activity of mutant p53.

The ectopic expression of ΔNp63 isoforms has been initially reported to inhibit p53 transactivation, leading to the early speculation that overexpression of ΔNp63 might simply be a mechanism to inactivate p53 [21] [21].

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