Sentence examples for mechanisms to activate from inspiring English sources

Conversely, inhibiting the MAPK pathway did not alter E2-dependent recruitment of ER to the PRL promoter array (data not shown), clearly showing that E2 and EGF operate through distinct molecular mechanisms to activate the transcriptional activity of ER.

The gene coding for SpoIIQ is absent in clostridia [ 1] therefore involvement of SpoIIQ is a Bacillus-specific innovation that likely does not represent the ancestral mode of cell-cell communication used to trigger late forespore sigma factor activation. Mechanisms to activate the late mother-cell sigma factor, σK, are apparently the most specialized of the sporulation sigma factors.

The p53 activators currently being tested for cyclotherapy all have distinct mechanisms to activate p53 and need to be tested in different combinations in vivo.

Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL.

Our study indicates that cells employ multiple and possibly mutually exclusive mechanisms to activate AKT (Fig. 7).

Another explanation is that these two families (based on the number of cysteine residues present) use different mechanisms to activate downstream process.

The extrinsic pathway begins with the release of tissue factor at the site of vascular damage and leads to the activation of factor X. The route provides an alternative mechanism to activate factor X, from the activation of factor XII.

Promotion of cytosolic translocation of LKB1 is a common mechanism to activate downstream LKB1 functions, as AMPK activation by metformin, peroxynitrile, or adiponectin also involves LKB1 cytosolic translocation [ 22, 64, 78- 80].

Persistent stimulus brings the UPR into focus; all the mentioned ERS sensor proteins use a unique mechanism to activate transcription factors and upregulate UPR target genes.

The system uses TMD mechanism to activate the control plates, which modify airflow around the deck to stabilize bridge motion.

This model shows how backpropagating action potentials in the long lateral dendrites of mitral cells, together with granule cell actions on mitral cells within narrow columns forming glomerular units, can provide a mechanism to activate strong local inhibition between arbitrarily distant mitral cells.