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However, further clarification of the molecular mechanisms, the complexity of apoE4 HO-1 interactions, as well as the impact of apoE genotype on inflammation using in vivo animal models and human trials is needed.
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The possible occurrence of damage mechanisms and the complexity of modeling these mechanisms to predict the overall composite creep behavior are also discussed.
Challenges in understanding its mechanisms include the complexity, as contributors are derived from both the donor and the recipient.
This brief summary of the PI3K-AKT pathway involvement in various important cell growth mechanisms highlights the complexity and importance of several nodes within this pathway.
The synergy between these mechanisms illustrates the complexity of BPA-induced endocrine disruption that should be taken into consideration when screening for environmental estrogens.
The presence of multiple gut brain liver mechanisms shows the complexity of the lipid-sensing system, which may have potentially increased the difficulty of managing obesity and obesity-related complications.
Breast cancer is a heterogeneous disease driven by a continuum of mutations and abnormal gene/protein expression that controls the tumourigenic phenotype and molecular mechanisms underpinning the complexity of its clinical behaviour [ 1].
From this it is clear that the high resistance to commonly used antifungals by biofilm-associated C. albicans cells cannot be attributed to the actions of just one mechanism, but is rather a comprehensive mechanism reflecting the complexity of the biofilm lifestyle itself.
This additional mechanism increases the complexity of implementation.
However, the problem with this mechanism is the complexity of implementation.
Medaka will serve as a powerful tool in which to dissect both the basic mechanisms and the complexities of apoptosis induction throughout evolution.
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