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10.7554/eLife.08298.010 Figure 4. sNPF and DTK modulatory mechanisms target different sensory neurons.
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Taking into account the complexity of pathogen recognition receptor (PRR) signaling in the innate immune response, it is likely that viruses have evolved a whole range of mechanisms targeting different PRRs and at different levels of their signaling pathways.
Notably, multiple independent mechanisms act together to locate Dscam[TM1] to dendrites; and diverse mechanisms are utilized to target different dendritic proteins to the dendrites.
It is just our first compound but we are working on other compounds that harness the same technology that would target different mechanisms in oncology.
The main rationale for using a number of medications in MS is that the involved treatments target different mechanisms and, therefore, their use is not necessarily exclusive.
The main rationale for polytherapy in MS is that the involved treatments target different mechanisms of the disease and therefore their use is not necessarily exclusive.
► These vaccines target different mechanisms of the allergic immune response.
A variety of AEDs have been designed to target different mechanisms involved in seizure development.
Given that BIRD-2 and BH3-mimetic agents target different mechanisms by which Bcl-2 inhibits apoptosis, we tested whether combining these agents would synergistically induce cell death in SCLC cells.
Understanding the factors leading to epidemic spread, as reported in Anderson and May's classic article [ 35], suggests that combination interventions that target different mechanisms of an epidemic may be synergistic at a population level.
Our model enables one to account for a variety of maintenance strategies that target different clogging mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com