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The cell cycle mechanisms sensing ribosomes or translation factors [73], [74] are connected with induction of genes required for DNA replication in late G1/S through G1 cyclin regulation, although protein interactions in yeast and metazoans differ [72].
The existence of different DR regimens that extend lifespan in yeast, flies, and mice raises the possibility that some of the mechanisms sensing the restriction of specific nutrients are conserved throughout evolution.
Initially the modulation by insulin-induced hypoglycemia of candidate hypothalamic genes previously shown to be regulated by metabolic/glycemic state and/or implicated in the neuronal mechanisms sensing and responding to extracellular glucose levels (18, 20 – 22) was investigated in two glucose-sensitive hypothalamic areas, PVH and ARC, in adult male CD1 mice.
Similar(57)
In D. melanogaster, the primary signal is provided by a gene counting mechanism sensing the number of X chromosomes (2 in females, 1 in males).
The redundancy belief means that we must already accept that at least two mechanisms sense metabolic rate (i.e., one in addition to carotid chemoreceptors).
However, RP deficiency does not always lead to nucleolar disruption (Fumagalli et al., 2009), suggesting that other mechanisms sense ribosomal stress as well.
However, mechanisms of sensing water vapor and other pollution gases are different.
Different detection mechanisms in sensing H2S and HNO were deeply investigated.
We show that this stability can be achieved through elementary mechanisms of sensing the sexual composition of the environment.
The studied oscillators were given comparable mechanisms for sensing an environmental signal through increased synthesis of the repressor(s).
Such mechanisms for sensing rapidly changing conditions might facilitate colonization into novel habitats.
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