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Although CHC contributes to p53 and NF-κB-regulated gene expression by different mechanisms, our data provide a second set of evidence for a role of CHC in gene regulation.
In summary, while c-GVHD and SSc may share common fibrotic mechanisms, our data suggest that rarefaction and loss of endothelial-specific markers may be specific to SSc and offer a clinical target in its own right.
Regardless of the mechanisms, our data show that plasma HPV DNA in viral associated CC should be an independent genetic marker to predict disease progression and clinical outcome.
While further studies are required to confirm these findings and specify their molecular mechanisms, our data suggest that the NA of A/Brevig Mission/1/18 might have differed already from its putative avian ancestor in birds.
Independent of the regulatory mechanisms, our data provide strong evidence for a potent function of the newly discovered AHR-NRF2-SLPI/SPRR2D/EPGN axin in the pathogenesis of MADISH.
It is known that clinical outcome of an HPV infection is the result of a complex balance between immune system responses and viral immune evasion mechanisms; our data suggest that CIN2 (particularly when associated with a non-HPV16 type) may represent a persistent poorly controlled HPV infection rather than a true preneoplastic lesion.
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Regardless of the mechanism, our data clearly show a distinct difference in alveolar mechanics in the normal versus the acutely injured lung, which leads us to our next question.
Regardless of the absorption mechanism, our data suggest that chylomicrons profoundly affect the transport of dietary antigens through the body.
In summary, whatever the mechanism, our data suggest that AhR/ARNT participates in the regulation of the αB-crystallin gene.
Regardless of mechanism, our data indicates that premature menopause represents another manifestation of accelerated aging in VDRKO mice.
Regardless of the mechanism, our data indicate that recognition and repair of denatured topoII breaks requires processing to produce free DSBs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com