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In the SPL paradigm is important to note that the use cases model needs to be adapted to incorporate the mechanisms of variability (Oliveira et al. 2013).
Identifying neural phenotypes affected by these polymorphisms would help advance our understanding not only of this specific genetic association but also of the broader neurogenetic mechanisms of variability in socioemotional behavior.
In this respect, several mechanisms of variability of c-Myc-Max-DNA binding avidity have been proposed (and, in some instances, experimentally substantiated) [ 12, 17, 18].
52, 53 Genetic mechanisms of variability include horizontal gene transfer of DNA sequences, 54 phase variation through a slipped strand mispairing mechanism, 55– 57 and transposition of mobile elements 58 that create surface structure variability of the organism, gene conversion, and antigenic variation via homologous recombination 21, 59– 62 and regulation by the two-component regulatory system.
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Michod summarises the fact that in neuronal group selection, synaptic change rules replace replication as a mechanism of variability of the 'unit of selection': there is correlation between the parental and offspring states of the same neuronal group even without multiplication [26].
With the advantages of rapid sample preparation procedures, automatic image analysis and data analysis, this method is applicable to study the molecular mechanism of variability of heart beat interval as well as to screen side-effect of cardiotoxicity of non-cardiovascular drugs.
In addition to a stable set of P. copri core marker genes common to all samples, a subset of variable marker genes was observed to co-occur in islands across the P. copri genome, suggesting genomic rearrangements as a mechanism of variability.
It will require both a substantial theoretical and modeling effort and high-resolution data to develop new capabilities for understanding mechanisms of solar variability.
Understanding the spatial patterns and mechanisms of climate variability requires absolute age control of these records.
Understanding the underlying mechanisms of phenotypic variability in drug response at the protein level is foremost in the establishment of personalized medicine [ 12].
Mechanisms of antigenic variability are well described for protozoan parasites and spirochetes [ 47], yet only one example has been reported for metazoan parasites thus far [ 48].
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