The mechanism of sorting particular RNA sequences into exosomes is not well understood at the moment, and is extremely challenging to study.
You could say that Mike's work especially Beavis and Butt-Head and his feature films Office Space and Idiocracy served as coping mechanisms of sorts, visual antidepressants that at various times in my life helped me say, "This guy's making a good living by making fun of all this crap.
In contrast to the extensive studies on the insulin-dependent signals regulating GLUT4 exocytosis, there is little consensus on the defining mechanisms of GLUT4 sorting into the insulin-responsive compartment (Foley et al., 2011; Stöckli et al., 2011).
Most job boards simply provide a couple of sorting mechanisms, such as popularity or salary.
The diversity and fundamental differences of some of the targeting signals and translocation systems indicate that at least several types of sorting mechanisms have originated independently.
10.7554/eLife.10811.022 Figure 9. Model for tug-of-war mechanism of cell sorting.
All this research, of course, is a defense mechanism of sorts, a way of sidling up to the forbidding subject of her brother with the tools of her journalistic trade, a way of maintaining distance while searching for a pattern in the carpet and an answer to the riddle: Why has their relationship been so fraught with silences and arguments?
Later the bad guys broke into his Gmail account, and eventually they erased the data on his iPhone, iPad and MacBook Air using Apple's remote-wipe feature — a self-destruct mechanism of sorts designed for use when a device has entered the wrong hands.
Overall, our study demonstrates an elegant mechanism for sorting of membrane cargo simply by modulating the relative number of engagement sites for each motor type.
The mechanism responsible for sorting of the cytosolic protein α-Synuclein into the extracellular vesicle pathway is unknown.
