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Identifying the underlying mechanisms of side effects is a challenging task, often because of the drugs' pleiotropic effects on a biological system.
It is known that network biology and pharmacology provides a way of developing drugs and understanding the mechanisms of side effects.
Findings from studies of structural or functional changes in normal organs after inhibition of VEGF signalling provide clues into mechanisms of side effects in cancer patients treated with VEGF inhibitors.
This type of imaging has been validated with known fiber tracts and animal models.[ 6, 13, 16] In this study, we sought to better understand the mechanisms of side effects from DBS in patients undergoing treatment for movement disorders.
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Both experimental and theoretical studies are made to analyze the mechanism of side lobe.
The mechanism of side effects and its correlation with pharmacogenetic data during sunitinib therapy need further studies.
Our studies revealed the first reliable resonance Raman (RR) evidence for heme-peroxo intermediate models and provided important insight into the structural mechanism of side-on and end-on (hydro peroxo-bound hydro peroxo-bound
Notably, the position S3 and S1 recognition pockets are entirely conserved between LexA Pa and LexA Ec, suggesting a common mechanism of side-chain recognition in forms of LexA from different species.
The new method includes deformation mechanisms of the side shell plating and the stiffeners attached.
The inferred ADR-pathway relations can be used to elucidate the mechanisms of drug side effects.
Motivation: Identifying the emergence and underlying mechanisms of drug side effects is a challenging task in the drug development process.
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