This reduced the scheduling conflicts, and has become a major mechanism of presentation at the annual meeting.
As endotoxins increase antigen processing in both MHC class II restricted antigen presentation and intracellular mechanisms of cross-presentation [ 27, 28], we mimic the ordinary antigen by giving traces of LPS (1 ng/mL) to endotoxin-free EndoGrade-ovalbumin.
Our increased understanding of the mechanisms of antigen presentation, particularly with the description of DC subsets with distinct functions, as well as their plasticity in responding to extrinsic signals, represent opportunities to develop novel vaccines.
These two mechanisms of antigen presentation reflect the different roles of the two types of T cell.
The Ig isotype profile reflects different mechanisms of antigen presentation and cognate interaction with helper T cells.
Thus, the presence and functional importance of AKAPs in DC open an exciting new avenue of research in understanding the molecular mechanisms of antigen presentation, T cell activation and DC biology.
Despite the data indicating that infected macrophages are relatively poor presenters of Mtb antigens to both CD8+ and CD4+ T cells, there is a robust acquired immune response associated with an Mtb infection which implies that alternative mechanisms of antigen presentation may be functioning within a granuloma.
Our studies have not identified alternative substrates or mechanisms of substrate presentation to suggest that in vivo the differences may not be significant.
To characterise aggrecan-specific T-cell hybridomas from BALB/c (H-2d) and DR1 transgenic mice to investigate the mechanisms of antigen presentation of arthritogenic CD4 T-cell epitopes of aggrecan.
Haemonchosis resistance has been associated with alleles of the ovine MHC OMHC1-1888) and with certain surface molecules of ovine leukocytes OLADRB2-2822), suggesthat thet the mechanisms of antigen presentation differ between breeds [ 25, 82].
