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Maini, P. K. & Solursh, M. Cellular mechanisms of pattern formation in the developing limb.
Chemically constructed cell-mimics, as non-living, biochemically simplified and engineerable systems, could serve as models to study mechanisms of pattern formation and collective responses, and lead to the development of novel sensors and self-organizing materials.
My laboratory explores the molecular mechanisms of pattern formation in developing embryos.
Basic drives and mechanisms of pattern formation events taking place e.g. during embryonic development can be studied in simplified experimental systems where complexity is reduced and the events are more accessible for quantitative analysis.
We develop a linear stability analysis for the interface dynamics that allows us to understand the mechanisms of pattern formation that arise from instabilities of spots, rings, stripes and fronts.
Recently, some criticism to the diffusion-degradation hypothesis for proteins, [31], suggest that it is important to search for other mechanisms of pattern formation, [22], [32], [33].
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Focusing on the binary polymer mixture films under the off-critical condition, the phase dynamics and wetting layer formation mechanisms of pattern-directed phase separation are numerically investigated.
Because morphological differences often involve the modification of basic developmental processes, careful study of these traits can also reveal developmental mechanisms of patterning, growth and size control (Stern 2000).
Therefore, the existence of common mechanisms of patterning in distantly related animals with similar life strategies does not necessarily provide iron-clad evidence for the presence of that developmental type in their last common ancestor.
The mechanism of pattern formation was also discussed.
Thanks to this realistic modeling method reflecting nature, the mechanism of pattern formation was found to be similar to real chemical processes.
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