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Indeed, both small integenic distance and bipromoter can be broadly related to high or low noise in poorly plastic genes, where uncoupling is rather associated to other mechanisms of modulating noise (HNLP genes exhibit higher translational efficiency).
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We suggest interface swapping in dimers could be a general mechanism of modulating the activity of transcription factors.
Histone modifications have been shown previously to be one mechanism of modulating transcription factors (TFs) and transcriptional control [6], [7].
This could be because of the transformation of the rela−/− cells with viral oncoproteins, which disrupts many transcriptional regulatory pathways, and resulted in the loss of this mechanism of modulating NF-κB function.
DNA methylation is an epigenetic modification where a methyl group is added to the 5-carbon position of cytosine and is a mechanism of modulating gene expression.
It is possible that through the mechanism of modulating neuroinflammation, EE housing is able to restore the disruption in energy metabolism induced by mTBI.
It is possible that through the mechanism of modulating neuroinflammation, EE housing was able to restore the disruption in energy metabolism and enhanced functional recovery after mTBI.
Taken together, these studies suggest that low vagus nerve activity may underlie elevated glucose levels, which provides the biological mechanism of modulating IGT using taVNS.
To investigate the mechanism of modulating vascular function in ApoE-KO mice treated with OCN, total and phosphorylated PI3K, Akt and eNOS expression were detected.
The data strongly suggested that a regulatory loop between miR-21 and STAT3 might provide an insight into the mechanism of modulating EGFR/STAT3 signaling.
We have recently suggested that gene-body methylation in the human genome may be associated with intragenic repetitive elements and that altered methylation in the gene-body may be a mechanism of modulating the level of transcription (24).
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