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The underlying mechanisms of microarray data variability are certainly of the same nature as the collective phenomena in physical systems but the ensemble of the processes involved is so complex that one would expect some compound distribution, far from the simple form expressed by the Gaussian prototype.
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For the investigation of molecular mechanisms of tissue injury by microarray analysis, we selected subpial cortical lesions with a zone of perilesional activity as defined above.
Also a recent study on the molecular mechanisms of TBT obesogenicity using microarray analysis in the 3 T3-L1 in vitro system revealed enrichment of Gene Ontology terms involved in energy and fat metabolism, and pathway analysis unveiled PPAR signaling as the most significantly enriched pathway [ 54].
To dissect the neuronal differentiation mechanisms of Znf179, we used a microarray to compare the global gene expression profiles between Znf179-knockdown and control cells, both of which were aggregated for 4 days in the presence of RA.
To additionally determine the effects of LXR ligands on breast cancer cells and to identify their potential mechanisms of action, we carried out microarray analysis of gene expression following treatment with the synthetic LXR ligand GW3965 in multiple breast cancer cell lines.
Inference of transcriptional control mechanisms from microarray expression profiling data alone has been attempted in the past using bioinformatic tools that typically search promoter regions or collections of evolutionarily conserved sequence blocks for overrepresented sequence motifs.
The diversity of microarray techniques now available offers multiple mechanisms for investigating the transcriptome, proteome, and metabo(l)nome.
In conclusion, our approach has the potential to further elucidate stress-specific mechanisms in plants via meta-analysis of massive amounts of microarray data.
We hypothesized that gene expression profiles would identify potential mechanisms of toxicity and used DNA microarrays and quantitative real-time PCR (qPCR) to generate profiles.
This study was designed to unravel the molecular mechanisms of the model obesogen TBT, using microarray analysis in the 3T3-L1 in vitro system, and to evaluate the use of toxicogenomics for obesogen screening.
The rapid accumulation of microarray data provides unprecedented opportunities to study the molecular mechanisms underlying disease pathogenesis and progression.
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