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Expanding our knowledge of the molecular mechanisms of malignancy and of resistance to therapy is crucial in guiding the successful design of anti-cancer drugs and new point-of-care diagnostics.
Taking advantage of cancer's mechanisms of malignancy by employing exogenous insulin as a biologic response modifier, it is possible to potentiate the cytotoxic effects of chemotherapeutic agents for improved treatment of cancer.
Further and deeper investigations of this organelle assure profound insights into the missing molecular mechanisms of malignancy.
The tequniques provide new avenues to facilitate the thorough understanding of the molecular mechanisms of malignancy at the systems-level.
Further study of the TCS, including its involvement in CL development and regression, may also help us understand mechanisms of malignancy and metastasis, and their treatment and prevention.
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However, no universal mechanism of malignancy predisposition in patients with PIDs has been determined.
Identifying genes or canonical pathways associated with advanced cancer can help to unmask the mechanisms of tumor malignancy as well as provide us with novel drug targets.
Identifying genes shared between advanced tumors and stem cells will not only unmask the mechanisms of tumor malignancy but also provide novel therapeutic targets.
Identifying genes abundant in late EECs can not only unmask the mechanisms of tumor malignancy but also provide us with novel therapeutic targets.
However, other mechanisms of enhanced malignancy, metastasis, and tumor resistance have emerged recently that also deserve consideration - namely, phenotypic plasticity and CSC.
A better understanding of the heterogeneity of the life expectancy in AD may highlight important pathologic mechanisms of the malignancy of AD and provide a more accurate prognosis for patients.
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