Acknowledgment of oxidative stress as a major contributor, not only of vascular complications, but also of suboptimal response to antiplatelet agents in T2DM, may open the way to designing and testing novel antithrombotic strategies, specifically targeting oxidative stress-mediated mechanisms of less-than-expected response to aspirin.
From a practical perspective, the mechanisms are of less relevance, though classical notions of fatigue would suggest an inability to perform at required exercise intensities precedes a decline in movement and possibly stroke play outcomes.
The mechanisms of a less efficient effect by GLP-1 to suppress glucagon secretion in diabetes remain unclear but further underline the importance of restoring glucagon hypersecretion in this disease.
Exploring staff perceptions of the safety and quality of their service has afforded important and unexpected insights into mechanisms of a less safe service and opportunities for a safer service.
Once-daily oral medications with an insulin-independent mechanism of action, less hypoglycemia, and weight loss benefits may simplify therapy and patient adherence, especially in this era of increasing obesity.
PYY is secreted by intestine cells after food intake, exerting a negative feedback (inhibits food consumption); however, it has been demonstrated that in obese individuals, PYY levels are lower than in normal people, making this mechanism of satiety less efficient in this case.
For many policy makers, understanding the mechanism is often of less importance whereas researchers are more likely to value uncovering the specific causal mechanisms or explanations that underlie causal descriptions.
While the physical understanding of electromigration mechanisms is less of a debate, technological challenges towards the fabrication of metal wires/vias able to carry the ever increasing current densities are enormous.
Shoulder injuries in rugby players are common, but the mechanisms of injury are less well understood.
The different mechanisms of uptake generate less hepato-selectivity in lipophilic statins [ 38].
