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Results showed that the prevalence of invasion (sefA and invA) and TTSS associated genes (hila, avrA and sopE) are high in internalized Salmonella isolates which indicates probable mechanisms of internalization of the isolates.
The technologies described in this chapter have been used to identify the mechanisms of internalization and intracellular compartments from which AB-toxins gain entry to the cytosol.
The present study provide indications of natural internalization of Salmonella spp. in betel leaf, though the mechanisms of internalization is yet to be elucidated.
We suggested that membrane curvature induced by basic peptides could be crucial to their mechanisms of internalization [23].
The sum of our results, therefore, argues that cells have evolved distinct mechanisms of internalization, by diversifying the functions of the same (at least in part) molecular machinery.
Interestingly, despite their high level of homology, the SPATE proteins demonstrate distinct mechanisms of internalization and interaction with the cytoskeletal proteins.
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Sunyach, C. et al. The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein.
The utilized CPP, attached cargo, concentration and cell type, all significantly affect the mechanism of internalization.
In the future, more information on the mechanism of internalization and intracellular trafficking of cell adhesion molecules will be exploited for delivering drug molecules to a specific type of cell or for diagnosis of cancer and heart and autoimmune diseases.
Mechanism of internalization of bacteria in the plant has not been elucidated clearly till now.
Future research is needed to further elucidate detailed mechanism of internalization of Salmonella spp. in betel leaf as well as other plant.
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