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The molecular mechanisms of delayed postconditioning are unknown.
Transient global ischemia, which often occurs during cardiac arrest when the brain is deprived of oxygen and glucose for a short period of time, involves several mechanisms of delayed neuronal cell death, such as excitotoxicity, free radical reaction, mitochondrial dysfunction, inflammation, and neuronal apoptosis [1], [2], [3].
We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging.
Central inhibition usually accompanies muscle inactivity-immobilization [ 39] possibly explaining the central mechanisms of delayed EMG onset during APAs in more affected muscle groups.
Therefore, the ability to directly monitor (and potentially image) thioether levels in situ will be of great benefit in future studies aimed at understanding the exact biochemical mechanisms of delayed neurodegeneration several days after ischemic insult.
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There is a growing body of evidence suggesting that low breast cancer awareness is associated with poorer survival in breast cancer through the mechanism of delayed presentation.
To further understand the underlying mechanism of delayed healing in elderly, we examined the migration characteristics of mesenchymal cells isolated from skin of burn patients.
Previous mathematical models of the somitogenesis clock that invoke the mechanism of delayed negative feedback predict that its oscillation period depends on the sum of delays inherent to negative-feedback loops and inhibitor half-lives.
12 The mechanism of delayed emesis has been most extensively investigated in patients receiving highly emetogenic cisplatin, but it also occurs with moderately emetogenic agents, including cyclophosphamide, anthracyclines, and carboplatin.
Previous mathematical models of the somitogenesis clock that invoke the mechanism of delayed negative feedback predict that the clock period can be approximated as a sum of the delays involved in processes such as transcription, splicing, translation and transport and the half-lives of inhibitors of clock gene expression (Lewis, 2003; Monk, 2003; Ay et al., 2013; Hanisch et al., 2013).
1, 27, 28 Thus the demonstration that CSD clusters occur and can reduce brain ptiO2may go some way toward explaining the variable association of delayed ischemia with proximal arterial vasospasm, 29 and the existence of such a dual mechanism of delayed ischemia.
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