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On the one hand, available crystal structures of ABC transporters have provided a structural basis for understanding the mechanisms of coupling ATP hydrolysis in the NBDs with the conformational change of the TMDs that is associated with cross-membrane transport of the substrate.
While riboswitches comprise an essential cis-regulatory mechanism in bacteria, other mechanisms of coupling metabolic state to post-transcriptional gene regulation may occur in eukaryotes.
Yet, the molecular mechanisms of coupling between substrate/modulator binding and catalytic activity remain to be elucidated.
In this paper, a new analytical method is proposed to examine the mechanisms of coupling between the powerplant and the vehicle chassis and subsystems.
General expressions are obtained for energies of the coupled substructures, and three different mechanisms of coupling are shown: spectral, spatial and excitation coupling.
Three major mechanisms of coupling, the friction coupling, the Poisson coupling and the junction coupling, as well as both distributed and concentrated external excitations are considered in this study.
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Mechanisms of coupled boundary sliding and migration based on the motion of edge-type extrinsic and intrinsic grain boundary dislocations are discussed.
Therefore, we could obtain better insight into synchronization mechanisms of coupled synthetic molecular systems distributed in host cells, and to provide further systematic analysis and control design to improve the synchronization robustness.
Here, we present crystal structures, molecular dynamics simulations and substrate binding assays of GltTk to localize the sodium binding sites, and provide insight in the mechanism of coupling between sodium and aspartate binding.
Pan1p, therefore, is responsible for the mechanism of coupling the vesicle coat to actin network in the early steps of internalization.
The proposed mechanism of coupling between electron transfer and proton translocation involves long-range conformational changes, coordinated in part by a long α-helix, akin to the coupling rod of a steam engine.
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