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Molecular and structural analyses of the Dot/Icm T4BSS have provided insights into the mechanisms of assembly and function.
Root microbiomes are formed from diverse microbial soil settings with extraordinary consistency, suggesting both defined mechanisms of assembly and specific microbial activity.
The results show that CtxB5 and the related heat labile enterotoxin LTB5 have distinct mechanisms of assembly despite sharing high sequence identity (84%) and almost identical atomic structures.
Subtle differences in the amino acid compositions of the two proteins are probably responsible for their two different mechanisms of assembly [30].
The following three aspects are important in understanding protein oligomers: (i) identification of the features of the interface (chemical and geometrical specificities), (ii) establishment of the assembly mechanism and (iii) determination of the molecular elements (e.g. amino acids) responsible for the mechanisms of assembly, and in particular for the association of interfaces.
David Eyre (Seattle, WA, USA) discussed the mechanisms of assembly and decay of the collagen fibre network in cartilage.
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While structural analysis techniques mainly aim to predict failure modes and mechanisms of assemblies, this research aims to further enhance such models by adding risk and cost measures to the structural analysis models.
Taken together, these studies define the architecture of a pore forming toxin and associated lectin domains, confirm the stoichiometry of the assembled oligomer as heptameric, and suggest a common mechanism of assembly for staphylococcal and Vibrio cytolytic toxins.
The mechanism of assembly of these particles is investigated.
This alternative mechanism of assembly is only feasible if M2 forms homodimers within the host cell.
However, the mechanism of assembly or dispersal of these structures is unclear, as is the relationship of these structures to disease outcome.
More suggestions(15)
system of assembly
arrangement of assembly
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mechanisms of membrane
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