Sentence examples for mechanisms modulating expression from inspiring English sources

Therefore, the formation and activity of Nrf2/Jdp2/MafK DNA-binding complexes may be the targets of additional regulatory mechanisms modulating expression of ARE-dependent genes.

Until recently, limited information has been available regarding mechanisms modulating miRNA expression during malignant transformation, primarily due to difficulties pertaining to identification of promoters and transcription start sites (TSS).

These observations raised the question whether certain regulatory mechanisms modulating the expression and degradation of iNOS might be circumvented by the lack of appropriate signaling through the mere presence of a proteasome inhibitor or by other less well-understood mechanisms possibly including factors affiliated with ER stress [42], [43].

Regulatory RNAs can act by different mechanisms, modulating gene expression either positively or negatively.

DNA methylation is one of the most studied epigenetic mechanisms modulating gene expression and has important health implications.

Interactions between neuropeptides and cytokines are well known (e.g. [ 39- 41]), and it has been suggested that regulatory neuroimmune pathways in the joints are important mechanisms modulating the expression of the arthritis [ 42].

Better understanding the molecular mechanisms modulating SNCA gene expression, may lead to novel therapeutic approaches based on reductions in SNCA levels [38] [40].

Taken together, these data provide novel insights into regulatory mechanisms modulating Foxp3 protein expression and thereby Treg numbers and suppressive capacity.

The combination of all central transcriptional regulatory mechanisms modulates the expression of more than 700 genes during sporulation.

Although some key transcription factors are known, the epigenetic mechanisms modulating TGFBIp and ECM expression remain unclear.

The aim of this study was to further enhance our understanding of regulatory mechanisms modulating AP-2 ε expression during the chondrogenic differentiation process.