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DNA repair mechanisms may fail leading cells to stop dividing, die or be mis-repaired, thus acquiring mutations that can result in malignant transformation (Begg et al. 2011).
This concept implies that if threshold levels of flux are exceeded, compensatory mechanisms may fail, leading to inadequate development.
There is a need to understand whether these compensatory mechanisms may fail, which could lead to adverse health effects.
Another perspective on neuroplasticity with degenerative diseases is that, with increasing pathology over time, compensatory mechanisms may fail or perhaps even become pathogenic via their effects on vulnerable neuronal populations, thereby destabilizing networks (Palop et al., 2006).
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Such phenomena show that the current risk avoidance mechanisms in SCF may fail.
In progressive external ophthalmoplegia, a disorder of the central nervous system mechanisms controlling gaze, the eyes may fail to move in one or another direction.
Despite these significant advances, we could not identify known TFBS motifs for several of the TFs, suggesting that these are either poorly characterized in TRANSFAC, that binding for that promoter is supported by heterogeneous mechanisms, or that reverse-engineering may fail to appropriately characterize the transcriptional targets of some TFs.
10 Existing mechanisms for quality assurance of healthcare may fail to meet the needs of care home residents.
Furthermore, private markets may fail to provide adequate mechanisms, such as loans, because of asymmetries of information.
During extreme floods, dikes may fail due to various breach mechanisms and cause considerable damage.
Evolved mechanisms to regulate macronutrient intake under natural conditions may fail to adequately operate in artificial environments involving high-energy density foods (e.g. maize grain).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com