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The importance of both mechanisms (loss and gain) is matter of debate.
The advantages of different escape mechanisms (loss of APM members vs. abrogation of β2m) are not understood.
The RUNX3 gene is regulated by three main mechanisms: loss of heterozygosity (LOH), protein mislocalization, and promoter methylation [ 3, 5, 8, 9].
Changes in phenotypes can arise de novo from altered gene expression profiles, rapid cell proliferation outpacing DNA repair mechanisms, loss of repair systems or checkpoints, alterations to chromosomal integrity and epigenetic events.
Similar(56)
This leads to a linear loss mechanism (loss that is independent of light intensity) in waveguides and resonant structures.
Several molecular mechanisms underlying loss of E-cadherin expression have been identified.
There must thus be mechanisms of loss of Wolbachia.
However, the mechanisms underlying loss of SOX2 expression and its target genes involved in gastric carcinogenesis remain largely unknown.
Therefore, the mechanisms underlying loss of SOX2 expression have not yet been defined in more than half of the cases.
Further work is needed to assess other potential mechanisms of loss of expression.
However, the molecular mechanisms underlying loss of Nuc-pYStat5 in breast cancer remain poorly defined.
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