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Currently, the molecular determinants for metastatic relapse and the underlying mechanisms, knowledge of which is essential for effective therapeutic intervention, requires further delineation.
Early in his career, Dr. Eisenbarth realized that for autoimmune endocrine diseases, and in particular for T1D, prevention and cure would be possible but required identification of key pathogenic mechanisms, knowledge of target autoantigens, and predictive markers.
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During this last decade significant progresses have occurred in the field of mechanism knowledge of allergen immunotherapy and in the search of new routes of administration or new types of formulation.
However, a comprehensive understanding of evolutionary mechanisms requires knowledge of how evolution shapes gene expression.
C. elegans has been instrumental in expanding our mechanism-based knowledge of PD, and this species is emerging as a good model of obesity.
In conclusion, this study reveals important mechanism-based knowledge of the synergism between MnSOD inhibition and clinically relevant anti-cancer agents.
Our analysis is not directly relevant to the first mechanism, but knowledge of the system suggests it is likely to be observed.
However, we intend to address this by measuring numerous hypothesised mechanisms of action (knowledge of depression, parenting skills, child's coping skills, attributional style) in both groups.
Grundmann assumes a lack of basic understanding of the political process and the mechanisms of knowledge policy.
Such a mechanism provides the knowledge of how much bandwidth is available between two nodes.
To understand the transcription mechanism, a detailed knowledge of the molecular structure of RNA polymerase II was needed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com