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Indeed, the evolution of such mechanisms is problematic when disease prevalence is low, as because of low prevalence their benefits are seldom experienced while their costs are always expressed.
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The absence of any generally accepted classification scheme for either modes/mechanisms of toxic action or of mechanisms of toxicity interactions is problematic as it produces a cycle in which research and policy are interdependent and mutually limiting.
Nearly 5% of units are designated for historic preservation, mostly in Manhattan.Mr de Blasio sensibly wants to boost supply through increased density, but the mechanism he has chosen is problematic.
However, the suggestion that this mechanism drives condensation in yeast is problematic for several reasons.
Pros: Small NGO that has done good work and gone out of its way to develop and support use of ChildInfo at country level Cons: CSF very dependent on one person Depends on software company subcontract UNICEF mechanism for contracting with CSF is problematic for both CSF and UNICEF Capacity of CSF to meet larger needs in use of ChildInfo is uncertain.
Granting to skeptics that democratic decision-making mechanisms might be problematic, they argue that deliberation is primarily what is needed to address the legitimacy deficit that global governance institutions face because of their disregard of democracy (see also Appiah 2006).
In particular, the molecular mechanism of how anterograde IFT is initiated is problematic to address experimentally.
Moving forward and testing the hypothesis of haploinsufficiency as a disease mechanism is difficult, and using mouse models is problematic.
There is no way to refine mechanisms and designating new pictograms for each new reaction type is problematic.
Our inclusion of transposition as a possible mechanism for gene order mutation in the Campanulaceae chloroplast genomes is problematic.
The omission is problematic.
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