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It is important to take a look at the level of complement inhibition especially when considering long-term treatment in chronic diseases as detrimental effects could be reduced by a certain degree of inhibition and still leave defence mechanisms intact [54].
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Conclusions: The stimulation of fetal swallowing in response to sublingual sucrose infusion suggests that taste-mediated ingestive behavior is functional in the near-term fetus and that both central and systemic appetite mechanisms are intact near term.
An increased understanding of plasticity of brain and spinal cord, and of the behavior of innate modular mechanisms in intact and injured systems, will likely assist in future developments.
Finally, although c-myc glands displayed a uniformly high epithelial cell turnover regardless of age, cell turnover was reduced with aging in nontransgenic and TGF-α mice, indicating that some growth and death regulatory mechanisms remain intact in TGF-α epithelia.
Because AIs do not deplete estrogen receptors, as does CC, normal central feedback mechanisms remain intact.
Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats [ 33].
aromatase inhibitors (AIs) do not antagonized estrogen receptors in the brain and, therefore, feedback central mechanisms remain intact.
The biological importance of these interactions has been established, for some mechanisms, using intact animals – although for some infections the absence of suitable models of infection precludes this.
Alveolar epithelial fluid clearance mechanisms are intact after mild to moderate lung injury and can be upregulated by β-adrenergic agonists [ 82, 83].
The increase in genes related to ROS quenching in benign cells suggests that these mechanisms are intact in benign cells, whereas they will either be absent in cancer cells or overridden by the ROS‐producing mechanisms.
Patients with proximal RTA are able to reclaim filtered bicarbonate when the filtered load is low and therefore their urine may be acid in presence of plasma acidosis, as distal acidification mechanisms remain intact [ 46].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com