Sentence examples for mechanisms including reducing from inspiring English sources

MDR can result from several distinct mechanisms, including reducing drug accumulation in tumor cells [1].

It may be activated through several cellular mechanisms, including reducing BubR1 protein levels [ 11, 26, 27], increasing ER-α transcription [ 28, 29], activating RHO GTPase [ 30], MAPK and ElK1 [ 31], inducing MMP expression [ 32], and constitutive activation of ERK1/2 [ 19].

Moreover, multiple mechanisms, including reducing the expression ratio of TGF-β1/BMP-7 and inhibiting the excessive activation of Hh signaling pathway, were involved in modulating the balance between EMT and MET by DWYG treatment, which further demonstrate the advantage of traditional Chinese medicine compound with multi-component and multi-target in the therapy for liver fibrosis.

This is in line with the knowledge that phenolics confer anti-diabetic effects via various mechanisms, including reducing oxidative stress and lipid peroxidation, defending pancreatic cells from oxidative damage, protecting lymphocytes from DNA damage, as well as preserving vascular functions in diabetic complications.

CS induces lung inflammation through different types of mechanisms, including reduced fibroblast proliferation and migration, and genetic mutations in the lung [ 3– 6].

This latter phenomenon is known as multidrug resistance (MDR) and can be conveyed by several mechanisms including reduced drug uptake, activation of DNA repair and defective apoptotic pathways.

134, 135 Therefore, amongst other effects, amylase inhibition could modulate GI function and gut peptide release, strengthening satiety and decreasing food intake by mechanisms including reduced gastric emptying.

Uric acid has been linked to AKI via crystal-independent mechanisms, including reduced renal blood flow and glomerular filtration rate (GFR), as well as crystal-dependent pathways [ 5].

MDR is known to be caused by several cellular mechanisms, including reduced drug accumulation, altered drug targets, and altered drug-induced apoptosis.

8 There is accumulating evidence from hundreds of randomised controlled trials that physical exercise may help in improving health via different mechanisms including reduced body fat per cent and improvement in many cardiometabolic risk factor levels measured from blood.

Antibiotic resistance is caused by many mechanisms, including reduced bacterial membrane permeability and gene mutations which change the targets of antibiotics and produce efflux proteins which pump the antibiotic out of the bacteria [ 2].