Low Hb level can cause HF via many mechanisms including tissue hypoxia and left ventricular failure [ 28].
These integral tumor-suppressive mechanisms include immunity, tissue organization, and the fitness of stem cell pools.
Pathways involved in the prothrombotic state of critically ill patients include tissue factor-mediated thrombin generation and impaired anticoagulant and fibrinolytic mechanisms [ 6].
Other potential mechanisms include hypoxia and tissue damage caused by oxidative stress in persons with lower lung function and COPD (1, 31) and a reduced ability for physical activity that may in turn lead to increased systemic inflammation (32).
Also, other pleiotropic and anti-inflammatory mechanisms, including dampened tissue factor expression by monocytes, which can attenuate the risk of thrombosis, have been described.
Tumor cell dissemination is mediated by a number of mechanisms, including local tissue invasion, lymphatic spread, hematogenous spread, or direct seeding of body cavities or surfaces.
Although possible mechanisms include effects on local tissue or the intracellular concentration of ADMA, the exact functional role of SNP rs1241321 and other DDAH1 SNPs requires detailed investigated in further studies.
Several mechanisms, including soft-tissue swelling, have been implicated as a cause of postoperative dysphagia.
Thus, patients with a large deletion at Xp22 might display MLS with ASD, due to the deletion of contiguous genes, although the highly variable phenotype of these patients could be influenced by several genetic mechanisms, including different tissue-specific X-inactivation and somatic mosaicism.
Proposed mechanisms include rapid tumour lysis and tissue necrosis in response to cytotoxics leading to rupture into the pleural cavity or bronchopleural fistula development [ 8].
