There are different mechanisms including molecular dynamics, vibration energy and phase behaviour responsible for such processes.
However, inflammation and autoimmune mechanisms, including molecular mimicry between periodontopathic bacteria and host molecules, are suggested to be the relevant mechanisms which link periodontitis to CVD".
Genetic and/or epigenetic characterisation is likely to further improve understanding including possible mediating mechanisms (including molecular factors such as epigenetic processes) and establishing the direction of causality.
Recent reviews have considered the possible contributions of different non-mutually exclusive mechanisms, including molecular mimicry, bystander activation, cryptic antigens, and epitope spreading [ 1- 3].
Adsorption of such molecules or particles on a surface depends on detailed mechanism including molecular transport from solution or suspension to the surface, surface diffusion of molecules under the effect of previously adsorbed molecules, reversible or irreversible attachment to the surface, and desorption of molecules from the surface when adsorption is reversible.
These mechanisms include their molecular chaperone activity, anti-apoptosis function and influence on the stability of client proteins [ 26].
Other top-rated pathways include molecular mechanisms of cancer, NF-κB signalling and several interleukin (IL) signalling pathways (IL-4, IL-6, IL-17).
In addition, top canonical pathways in the MM group include molecular mechanisms of cancer, Wnt/beta-catenin signaling, Dopamine-DARPP32 feedback in cAMP signaling, and in G-protein-coupled receptor signaling.
These include Molecular Mechanisms of Cancer (P = 7.1 × 10-7), p53 Signaling (P = 7.1 × 10-7), Basal Cell Carcinoma Signaling (P = 1.27 × 10-5), GADD45 Signaling (P = 1.43 × 10-5), and Role of NANOG in Mammalian Embryonic Cell Pluripotency (P = 4.54 × 10-5) (see Additional file 10).
The defense mechanisms include low-molecular-weight antioxidants, for example vitamins C and E, coenzyme Q10, and glutathione, as well as antioxidant enzymes, such as glutathione peroxidase, catalase, and superoxide dismutase [ 136].
