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Underlying mechanisms include induction of peripheral insulin resistance by hypoxia, 3 acidosis 4 and systemic inflammation.
Other mechanisms include induction of membrane glycoprotein, heat shock proteins, and multidrug resistance membrane pumps.
The proposed mechanisms include induction of apoptosis of tumor cells and lymphocytes, inhibition of angiogenesis and stimulation of the cellular compartment of the immune system [ 9- 14].
Although the pathogenesis of host cell injury remains largely unknown, proposed virulence mechanisms include induction of proinflammatory cytokines by phagocytes (21 ), oxidative damage to host cells by production of toxic by-products (22 ), and cleavage of host DNA through nucleases (23 ).
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Although several mechanisms, including induction of apoptosis, have been proposed for the anti-carcinogenesis activities of ITCs, detailed upstream triggering events are still not fully understood.
TP53 is involved in maintenance of genomic integrity via several mechanisms including induction of cell cycle arrest in response to DNA damage, DNA repair and regulation of apoptosis.
Antibodies against tumor-associated antigens can attack tumor cells via a number of mechanisms including induction of apoptosis in tumor cells and engaging Fc receptors on immune cells [50], [51], [52], [53].
SFN was first identified as a potent inducer of phase 2 detoxification enzymes [8], and studies have also found other anti-carcinogenic as well as anti-oxidant mechanisms including induction of caspases, induction of glutathione S-transferase, inhibition of cytochrome P450 isoenzymes and reduction of the DNA binding ability of nuclear factor-κB [6] [8].
SFN induces several cellular protective mechanisms, including induction of the Keap1-Nrf2 pathway (Baird & Dinkova-Kostova, 2011).
This difference between the two trajectories might be explained by H-RAS induction that can inhibit cell proliferation through different mechanisms including induction of p21 through p53 [ 32].
TNC influences cell migration, proliferation and cell signalling pathways through a variety of mechanisms including induction of pro-inflammatory cytokines [ 37].
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