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Important mechanisms include excessive microglial activation, impaired cerebral perfusion, blood brain-barrier dysfunction, and altered neurotransmission.
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Hypertension develops by several mechanisms, including excessive renin concentrations which lead to activation of the renin-angiotensin system, increased vascular sensitivity to catecholamine, and increased concentrations of aldosterone [ 5- 11].
47 Chronic kidney disease facilitates high blood pressure through many mechanisms including excessive intravascular volume, increased endothelin production, activity of the renin-angiotensin system and sympathetic nervous system and decreased vasodilators, nitric oxide production and endothelial function.
Possible pathogenetic mechanisms linking smoking with interstitial fibrosis include excessive oxidative stress [ 18, 19] and the modulation of oxidative stress by the up-regulation of protease inhibitors (such as tissue inhibitor of metalloproteinases) [ 20] or a direct effect of smoking on the extracellular thiol/disulfide redox environment [ 21].
These include excessive vasoconstriction and remodeling of the pulmonary arteriolar wall, primarily by a mechanism of smooth muscle proliferation within the medial layer.
The big culprits include excessive online gaming, watching pornography, and e-mail.
Two other extremes that serve as smokescreens include excessive tolerance to sexual promiscuity and excessive prudishness.
Other examples include excessive licking, self-mutilation and trunk-swinging.
Bad ways include excessive drinking, drugs and other addictive outlets.
Other dietary influences include excessive calcium intake, excessive mineral intake, and an imbalance of vitamin D metabolites.
Muscarinic manifestations include excessive salivation, meiosis and diarrhea.
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