Efforts to counteract resistance mechanisms to abiraterone include combination strategies with c-MET blockade, heat shock protein inhibitors, or histone deacetylase inhibitors aimed at disrupting the AR transcription complex.
Multiple mechanisms including a combination of raised intracranial pressure, subarachnoid hemorrhage, stretching of nerves in sinus walls and inflammation of sinus walls are most likely responsible for variable patterns of headache among these patients.
High sorption of metal ions (Cu, Co, Cd, Zn, Mn, and Pb) on MWCNTs and Hg2+ on nC60 have also been reported; mechanisms included a combination of chemical complexation, electrostatic attraction, and/or cation-π interaction.
Given the complex pathophysiology of acne, novel topical therapies should include combination products that target multiple pathogenetic mechanisms.
These mechanisms include complexation, coordination, physiochemical mechanisms, electrostatic interaction, ion exchange combinations, micro-precipitation, adsorption and chelation (Vijayaraghavan and Yun 2008; Wang and Chen 2006).
Putative C9ORF72 expansion pathogenic mechanisms include loss of C9ORF72 protein function, sequestration of nucleic acid binding proteins due to expanded hexanucleotide repeats, or a combination of the two.
Indeed, in most low-income settings, the remuneration of health workers is not composed of a single type of payment but includes combinations of payment mechanisms, which differ by source of funding, contract agreements, features such as regularity and inclusion of "deferred" compensation (pensions), and task requirements.
#including combinations with diclofenac.
They suggested a combination of mechanisms including surface charge change and mineral dissolution, the former being the most effective and the latter having a positive but insignificant effect.
There is also ample evidence for lineage diversification via a combination of mechanisms including both dispersal and vicariance [ 18].
