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Additional proposed mechanisms include active transport of cytokines into the OVLT or activation of cytokine receptors in endothelial cells of the neural vasculature, which than transduce signals to the brain [ 19].
Endothelial molecular control mechanisms include active transendothelial transport systems and tight junctions.
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Such a scattering of the results may be ascribed to (i) different dimensionality of the models; (ii) different values of the parameters (see the below sensitivity study); (iii) different biophysical mechanisms included (active pumping, filtration velocity, membrane permeabilities, membrane partition coefficient).
The innate immune response constitutes the first line of defense against invading pathogens and consists of a variety of immune defense mechanisms including active endocytosis by macrophages and granulocytes.
Candida cells growing in a biofilm are known to be highly resistant to antifungal drugs through different mechanisms including active extrusion through efflux pumps [ 27].
Systemic cytokines can affect the brain through several mechanisms, including active transport across the blood brain barrier [ 103], through leaky areas in the blood brain barrier in the circumventricular organs [ 104] or through the activation of neural pathways such as the vagal nerve [ 105].
The mechanisms of this transport depend on the size of the object being transported and include active endocytosis/exocytosis and passive transport (this mechanism is predominant in red blood cells).
The mechanism behind the improvement has not been determined but may include active cough suppression, reduced cough sensitivity or increased cough threshold from reduced laryngeal irritation.
However, resistance to chemotherapy may also be due to other mechanisms, including highly active drug pumps [ 15].
Evident inhibition mechanisms include the reduction of active site number by increasing the crystallite size and the site blockage by formed boron oxide.
Identified examples of systems with active tilting mechanisms include 1.
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