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It is found that a combination of well-perfused and poorly perfused mechanisms in tumor vasculature will result in the coexistence of two time constants.
However, its role and mechanisms in tumor progression are poorly understood.
This discrepancy may have been caused by the heterogeneity associated with immune-escape mechanisms in tumor cells.
Cell death from ionizing radiation exposure is primarily due to abnormalities within repair mechanisms in tumor cells.
The PI3K/Akt signaling provides important survival mechanisms in tumor cells by promoting growth and metastasis, and reducing sensitivity to chemotherapies [ 14, 15].
As this model is syngeneic in BALB/c mice, it can be used to study the antitumor immune mechanisms in tumor growth and metastasis 33.
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The results hint to different molecular mechanisms in tumors induced at low doses compared to moderate and high doses with a preferential occurrence of CLIP2 expression.
This study showed a clear dose-response relationship for the CLIP2 radiation marker in post-Chernobyl papillary thyroid carcinoma cohorts for young patients and hints to different molecular mechanisms in tumors induced at low doses compared to moderate/high doses.
Recently, several studies have reported that mRNA is released by an active mechanism in tumor cells [9] [11].
Of note, miR-210 expression is induced by hypoxia, which was shown to induce UPR as a pro-survival mechanism in tumor cells [18].
Methylation of tumor suppressor genes is a common mechanism in tumor development.
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