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Yu, S. et al. Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.
Lin HK, Hu YC, Lee DK, Chang C. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells.
Further insight into downstream pathways of TGF-β1 and mechanisms in prostate tissue homeostasis is important for understanding the role of this factor in prostate disease progression.
Treatment with DZNep led to the reactivation of genes silenced by epigenetic mechanisms in prostate cancer.
The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident.
This suggests that the full force of transcriptional silencing mechanisms in prostate cancer may not yet be fully recognised.
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Future studies are warranted to test the validity of such mechanisms in prostate-cancer cells and to determine whether these are features that are restricted to neoplastic prostate epithelial cells.
Although induction of these chemokines by IL1β has not been demonstrated to date, several pieces of evidence support the relevance of this mechanism in prostate cancer progression.
Voronov et al. [17] have shown that IL1β is required for tumour invasiveness and angiogenesis in a mouse breast cancer model and provided evidence for the same mechanism in prostate cancer.
DNA methylation is an important epigenetic mechanism in prostate cancer (PCa) progression.
Several studies indicate that DNA hypermethylation is an important mechanism in prostate cancer initiation and progression.
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