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The HVC enrichment of the corticotropin-releasing hormone binding protein (CRHBP; Fig. 2B) and of a mineralocorticoid receptor (NR3C2) suggests as yet undefined roles of corticoid-related mechanisms in modulating HVC properties, possibly in a very distinct and sparse subset of cells.
Together, these studies provide evidence for lung-specific mechanisms in modulating Rab-regulated receptor trafficking.
In this review, we focus on the molecular aspects of the type I IFN system and its effector mechanisms in modulating HCV replication.
This suggests that FAC alters autophagy in an ATG5/ATG7-dependent and a Ras-independent manner, which contributes only a modest effect to FAC-induced cell survival implicating other mechanisms in modulating FAC-induced cell death response.
Mounting evidence now suggests an important role for epigenetic mechanisms in modulating and transmitting signals for B lymphocyte tolerization to self-antigens.
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PHD2 is regarded as the main cellular oxygen sensor that regulates HIF-1α degradation in normoxia [10], [14], thereby suggesting that the inactivation of PHD2 may provide a critical mechanism in modulating HIF-1α.
This GCK-mediated liver-to-BAT neuronal relay system provides a novel mechanism in modulating obesity predisposition in mice.
We discuss possible implications of this mechanism in modulating TCR output signals towards conventional T-cell development and differentiation.
Thus, the activity assay provides further independent support that Y is present in substoichiometric amounts relative to β and suggests an important role for a maintenance mechanism in modulating the levels of Y and, as a consequence, the rates of deoxynucleotide production.
Consistent with these findings, the crystal structure of biotin carboxylase domain of hACC2 has revealed that the phosphorylation of Ser222 disrupts the polymerization of ACC2, a widely recognized mechanism in modulating catalytic function (Cho et al. 2010; Lee et al. 2008).
However, the molecular mechanisms involved in modulating the host cellular processes and evasion of the immune response have not been clearly established.
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