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Again, this indicates that the parental tumor harbored multiple resistance mechanisms in distinct subclones.
We also found that phenotypically identical pain syndromes are induced through different molecular mechanisms in distinct sets of sensory and sympathetic neurons.
Although the identity of the fibroblast sheddase remains to be determined, these results highlight that shedding of a cell surface protein may occur by very different mechanisms in distinct cell types.
By comparing s.c. B16 tumor growth in syngeneic C57BL/6J mice, allogeneic FVB/NJ mice, semi-syngeneic C57 × FVB F1 mice, fully chimeric C57/FVB mice and C57/FVB chimeric mice devoid of C57 skin, a complex interplay of local immune tolerance and defense mechanisms in distinct tumor rejection is suggested.
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Overall, all this hints to a yet uncharacterized mechanism in distinct E. coli strains that provides for rapid phenotypic switching of expression levels of CsgD and therefore high-curli fibre production at 37°C.
Quantitative changes in the avoidance response could be due to either a single molecular mechanism proportionately changing with intensity of the stimulus, or multiple separate molecular mechanisms operating in distinct temperature ranges, which converge onto a qualitatively similar avoidance response.
Here, we show that these two silencing mechanisms result in distinct chromatin structures.
Our data strongly suggest the existence of pVHL-independent mechanisms, resulting in distinct gene expression outputs which reflect common biologic pathways in renal cell cancer.
Notably, dynein/dynactin dysfunction did not alter distribution of another dendritic transmembrane protein Rdl (Resistant to Dieldrin), supporting involvement of diverse mechanisms in locating distinct molecules to the dendritic membrane.
So doing allows for concrete representations of multilevel hepatic mechanisms in many distinct experimental contexts, without degrading the ability to parameterize an ISL so as to accurately represent a particular context.
Epigenetic machinery is involved in the establishment of this pattern, and manipulation of its mechanism results in distinct patterns of var gene expression.
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