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Although PAX6 mRNA does not exhibit a gradient of expression from 9 PCW onwards in humans, it is possible that downstream transcription factors may be responsible for further arealization mechanisms in differentiating neurons migrating towards the pial surface.
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The present study was designed to elucidate the cellular and molecular mechanisms of neuritogenesis in differentiating neurons.
By using the systems approach to examine global miRNA-target mRNA network in the context of the hallmarks of cancer [ 24], we identified several important network clusters involved not only in antiestrogen resistance mechanisms but also in differentiating resistance to SERMS and SERDS.
Our data show that a similar mechanism appears to operate in differentiating myoblasts, in which Msk1 regulates a H3K27/H3S28 methyl/phospho switch to allow removal of the PRC2-Ezh2 complex and muscle gene activation.
Human cleavage stage embryos have 26.5% cells with double staining for XIST signals (van den Berg et al. 2009) that may be reminiscent of a counting and choice mechanism such as found in differentiating ES cells.
This suggested that physical clustering is a frequent mechanism for gene co-regulation in differentiating keratinocytes.
However, because of the difficulty in differentiating between these mechanisms in flood test, most authors prefer to use a single term of retention or adsorption to describe the loss of polymer in porous media.
The precise mechanism of selective silencing of PER2 in differentiating HESCs remains to be defined.
Dkk1 mRNA is upregulated even in D3-proliferating NSCs never directly exposed to Dex, as well as in differentiating NSCs, suggesting that other mechanisms may be also involved.
Future research may establish that networking is an important component of retention, valuable in differentiating course experiences, and a mechanism for evaluating the broader societal impacts of CUREs.
One mechanism that might account for these results would be if 5T4 molecules facilitate stable cell membrane expression of CXCR4 molecules in differentiating ES cells.
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