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Integration of existing approaches in biomechanics and high-throughput transcriptomics/proteomics enables us to profile cell phenotype under complicated mechanical stimuli and to elucidate the mechanisms in cell type-specific mechanobiology (Davies et al., 2005).
In Glover's lab, Bettencourt-Dias worked to identify novel mechanisms in cell cycle regulation doing genetics studies in drosophila.
It will be important to decipher known, or identify new regulatory mechanisms in cell types that are responsible for unique circadian behaviors.
Cybernetic models of bioreactors are appealing due to their capacity to account for regulatory mechanisms in cell metabolism by modeling the synthesis of enzymes and their activities.
More studies are needed to confirm the existence and activation of BMP4 signaling in preimplantation embryos and to investigate its functions and the underlying molecular mechanisms in cell lineage determination.
Although this is the first report demonstrating that Gβγ leads to CREB activation, and that CRF and CRFR1 signal via Gβγ in neurons, there have been reports of CRF acting through Gβγ-dependent mechanisms in cell lines expressing recombinant protein.
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The team had identified that chloride channels – key mechanisms in cells – were somehow involved in tumours invading brain tissue.
However, level of free radicals often overcome the defense of scavenging mechanisms in cells exposed to environmental stressors or under certain pathophysiological conditions, resulting in oxidative stress.
This analysis suggests yet unidentified mechanisms in cell-type and v-rDNA-specific regulation.
We test our working hypothesis by computationally screening three overlapping qualitative models of cell-cycle control architectures; we employ monte-carlo sensitivity analysis and k-means clustering to rank-order mechanisms in cell-cycle and then contrast the predicted fragile and robust mechanisms with literature.
Numerous adaptive mechanisms in cells alter gene expression in response to potentially lethal stressors.
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