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Interestingly, the DS break mechanisms in budding yeast and fission yeast are different.
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It will be interesting to observe all steps of dynein binding and thus to complete the picture of the targeting mechanism in budding yeast.
Perhaps a similar mechanism exists in budding yeast.
The mechanisms of such temporal regulation in budding yeast, fission yeast and metazoan cells have been reviewed [ 111, 112].
This manuscript takes a computational approach to study the mechanisms responsible for chromosome condensation in budding yeast.
This property of the model is an indication that it is correctly representing the sequence of dependencies in the molecular mechanism underlying cell cycle progression in budding yeast.
The mechanisms that ensure mating-type repression in budding yeast, also serve to mediate position-dependent repression at telomeres (Aparicio et al, 1991; reviewed in Huang, 2002; Rusche et al, 2003).
Nonetheless, the mechanism for DDK recruitment is different in budding yeast and fission yeast, because in fission yeast the heterochromatin protein Swi6 binds to and recruits DDK to pericentromeric regions [ 79, 135].
The longer CLS in 2% compared to 10% glucose SC or YPD cultures in the absence of a change in medium pH reveals an additional mechanism by which CR extends CLS in budding yeast related to reduced growth signaling by glucose rather than acetic acid.
Our model is specific to the replication machinery in budding yeast, but the mechanisms driving this process are highly conserved throughout Eukarya.
However, recombination-independent mechanisms for chromosome end protection also occur in budding and fission yeasts (Jain et al. 2010; Lee et al. 2008; Maringele and Lydall 2004b).
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