Sentence examples for mechanisms given that from inspiring English sources

It is important to understand the underlying mechanisms given that deregulation of the mechanical properties of the extracellular matrix (ECM) is implicated in various diseases, such as cancer and fibrosis.

Many studies have investigated that TNF-α antagonists can cause cell lysis by apoptotic, ADCC, CDC and outside-to-inside signaling mechanisms given that it has the binding ability to transmembrane TNF-α [1], [20], [21], [22].

However, the authors do not rule out D3 mechanisms, given that pergolide may have greater D3 than D1 receptor affinity [ 24].

Regardless of the exact mechanisms, given that elevated expression of c-Myc is ubiquitously observed in many B cell malignancies [ 45], our findings suggest that AD 198 may have wide therapeutic application in B cell neoplasms.

The increase of IFG/insula activation with methylphenidate is likely mediated by both noradrenergic and dopaminergic mechanisms, given that in frontal regions both in humans (15,69,70) and in animals (69,70) methylphenidate increases noradrenaline equally or more than dopamine via reuptake inhibition of noradrenaline transporters, which clear both catecholamines.

It is important to understand whether maternal diabetes (and indeed greater adiposity, which is not addressed here) is associated with lasting greater offspring adiposity and more adverse cardiometabolic health via intrauterine mechanisms given that developmental overnutrition could perpetuate the obesity epidemic across future generations.

A test case based on various WM approaches in Israel (several implementations of mixed and separated waste) shows that local characteristics significantly influence WM costs, and therefore the optimal scheme is one under which each local authority is able to implement its best-fitting mechanism, given that national guidelines are kept.

This would be consistent with genetic damage as a mechanism, given that early SABs are more likely to have chromosomal abnormalities or birth defects (Byrne et al. 1985).

In fact, a tight binding between the RBR and UBA might not be favourable for a competitive inhibition mechanism, given that the UBL of HOIL-1L and the UBA of HOIP interact in the low micro-molar range.

Since their discovery, the FG Nups have been identified as the key functional constituents of the NPC gating mechanism given that their FG-repeat motifs (i.e., GLFG, FxFG, and FG) exert binding interactions with the Kaps.

NIK-mediated activation of the noncanonical NF-κB pathway (phosphorylation of IKKα and subsequent limited proteolysis of NFKB2) is not essential for the transformation mechanism, given that some BIRC2/3 mutants with full transforming potential failed to activate NF-κB.