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The question of the mechanisms generating cell type-specific patterns of lymphocyte antigen receptor gene rearrangement and expression has been the focus of much study.
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► Spindle orientation is a key mechanism for generating cell diversity and balancing self-renewal and differentiation of neural stem cells.
Calcium ions have been increasingly implicated as a mediator of the mechanisms generating lethal cell injury under a variety of pathologic circumstances.
The term Glycomic Code has been used to define the set of mechanisms that generate cell wall architecture (the combination of polymers of different types) and biological function.
Phylogenetically independent lineages of C4 plants have co-opted homologous mechanisms to generate cell specificity (Brown et al., 2011) as well as the altered allosteric regulation of C4 enzymes (Christin et al., 2007) indicating that parallel evolution underpins at least part of the convergent C4 syndrome.
The RNP complexes have a mechanism to generate cell polarity and can provide the basis for patterning during embryonic development [26].
The complexity of the interaction is the result of paracrine activation mechanisms generated via sheer cell-cell contact as well as of numerous autocrine mechanisms – nearly any soluble mediator shows abnormalities.
DOI: http://dx.doi.org/10.7554/eLife.06970.002 Asymmetric cell division is a mechanism that generates cells with different properties.
During development two major mechanisms are involved to generate cell diversity: asymmetric cell divisions, leading to the formation of two different daughter cells, and cellular interactions, leading previously identical cells to adopt distinct fate.
22 Similar mechanisms generating daily rhythms are present in most cells.
This mechanism was utilized to generate cell lines with frame-shift mutations in the PD-L1 gene locus Cd274.
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